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Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament

27 Oct 2016

Abstract excerpt

Homologous recombination (HR) is a crucial pathway for double-stranded DNA break (DSB) repair. During the early stages of HR, the newly generated DSB ends are processed to yield long single-stranded DNA (ssDNA) overhangs, which are quickly bound by replication protein A (RPA). RPA is then replaced by the DNA recombinase Rad51, which forms extended helical filaments on the ssDNA. The resulting nucleoprotein...

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PMID: 27903895
DOI: 10.1093/nar/gkw1125

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Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filamentPMID 27903895Read ↗

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