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Article

The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.

Molecular cell - 4 Mar 2021

Roy Upasana, Kwon Youngho, Marie Lea, Symington Lorraine, Sung Patrick, Lisby Michael, Greene Eric C

Abstract excerpt

Homologous recombination (HR) is essential for maintenance of genome integrity. Rad51 paralogs fulfill a conserved but undefined role in HR, and their mutations are associated with increased cancer risk in humans. Here, we use single-molecule imaging to reveal that the Saccharomyces cerevisiae Rad51 paralog complex Rad55-Rad57 promotes assembly of Rad51 recombinase filament through transient interactions,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33421364
DOI: 10.1016/j.molcel.2020.12.019
PMCID: PMC8262405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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