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Distinct RAD51 Associations with RAD52 and BCCIP in Response to DNA Damage and Replication Stress

15 Apr 2008

Abstract excerpt

RAD51 has critical roles in homologous recombination (HR) repair of DNA double-strand breaks (DSB) and restarting stalled or collapsed replication forks. In yeast, Rad51 function is facilitated by Rad52 and other "mediators." Mammalian cells express RAD52, but BRCA2 may have supplanted RAD52 in mediating RAD51 loading onto ssDNA. BCCIP interacts with BRCA2, and both proteins are important for RAD51 focus...

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PMID: 18413737
DOI: 10.1158/0008-5472.can-07-6505

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