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Article

Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins.

Molecular cell - 4 Mar 2021

Belan Ondrej, Barroso Consuelo, Kaczmarczyk Artur, Anand Roopesh, Federico Stefania, O'Reilly Nicola, Newton Matthew D, Maeots Erik, Enchev Radoslav I, Martinez-Perez Enrique, Rueda David S, Boulton Simon J

Abstract excerpt

Homologous recombination (HR) is an essential DNA double-strand break (DSB) repair mechanism, which is frequently inactivated in cancer. During HR, RAD51 forms nucleoprotein filaments on RPA-coated, resected DNA and catalyzes strand invasion into homologous duplex DNA. How RAD51 displaces RPA and assembles into long HR-proficient filaments remains uncertain. Here, we employed single-molecule imaging to...

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Share to Caenorhabditis elegans Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33421363
DOI: 10.1016/j.molcel.2020.12.020
PMCID: PMC7941204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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