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Article

Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing

5 Dec 2013

Abstract excerpt

Most mitotic homologous recombination (HR) events proceed via a synthesis-dependent strand annealing mechanism to avoid crossing over, which may give rise to chromosomal rearrangements and loss of heterozygosity. The molecular mechanisms controlling HR sub-pathway choice are poorly understood. Here, we show that human RECQ5, a DNA helicase that can disrupt RAD51 nucleoprotein filaments, promotes formation of...

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PMID: 24319145
DOI: 10.1093/nar/gkt1263

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Related research

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Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealingPMID 24319145Read ↗

RECQ5: A Mysterious Helicase at the Interface of DNA Replication and TranscriptionSemantic proximity Read ↗

RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.Semantic proximity Read ↗

Novel insights into RAD51 activity and regulation during homologous recombination and DNA replicationSemantic proximity Read ↗

The role of DNA repair by homologous recombination in oncogenesis.Semantic proximity Read ↗

RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structuresSemantic proximity Read ↗

Human RAD52 stimulates the RAD51-mediated homology searchSemantic proximity Read ↗

The Set2-RPB1 Interaction Domain of Human RECQ5 Is Important for Transcription-Associated Genome StabilitySemantic proximity Read ↗

Human RECQL5β stimulates flap endonuclease 1Semantic proximity Read ↗

Human RecQ Helicases in DNA Double-Strand Break RepairSemantic proximity Read ↗

PARP1 regulates RECQL4 recruitment for DNA double-strand break repairSemantic proximity Read ↗

ATRX and RECQ5 define distinct homologous recombination subpathwaysSemantic proximity Read ↗

Human RECQL5 participates in the removal of endogenous DNA damageSemantic proximity Read ↗

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