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Article

High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy.

Nucleic acids research - 2 Nov 2016

Short Judith M, Liu Yang, Chen Shaoxia, Soni Neelesh, Madhusudhan Mallur S, Shivji Mahmud K K, Venkitaraman Ashok R

Abstract excerpt

Homologous DNA recombination (HR) by the RAD51 recombinase enables error-free DNA break repair. To execute HR, RAD51 first forms a presynaptic filament on single-stranded (ss) DNA, which catalyses pairing with homologous double-stranded (ds) DNA. Here, we report a structure for the presynaptic human RAD51 filament at 3.5-5.0Å resolution using electron cryo-microscopy. RAD51 encases ssDNA in a helical filament of...

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Share to Adenosine Diphosphate
Share to Cryoelectron Microscopy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Single-Stranded

Share to Homologous Recombination

Share to Molecular Conformation

Share to Rad51 Recombinase

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Share to Repetitive Sequences, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 27596592
DOI: 10.1093/nar/gkw783
PMCID: PMC5100573

Genes

RAD51
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy.PMID 27596592Read ↗

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