Article
Rad52-Rad51 association is essential to protect Rad51 filaments against Srs2, but facultative for filament formation.
eLife - 9 Jul 2018
Ma Emilie, Dupaigne Pauline, Maloisel Laurent, Guerois Raphaël, Le Cam Eric, Coïc Eric
Abstract excerpt
Homology search and strand exchange mediated by Rad51 nucleoprotein filaments are key steps of the homologous recombination process. In budding yeast, Rad52 is the main mediator of Rad51 filament formation, thereby playing an essential role. The current model assumes that Rad51 filament formation requires the interaction between Rad52 and Rad51. However, we report here that Rad52 mutations that disrupt this...
Topics
- Alleles
- Amino Acid Sequence
- DNA Breaks, Double-Stranded
- DNA Helicases
- DNA, Fungal
- Gene Conversion
- Homologous Recombination
- Models, Biological
- Mutant Proteins
- Mutation
- Protein Binding