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Article

Rad52 Oligomeric N-Terminal Domain Stabilizes Rad51 Nucleoprotein Filaments and Contributes to Their Protection against Srs2.

Cells - 11 Jun 2021

Ma Emilie, Maloisel Laurent, Le Falher Léa, Guérois Raphaël, Coïc Eric

Abstract excerpt

Homologous recombination (HR) depends on the formation of a nucleoprotein filament of the recombinase Rad51 to scan the genome and invade the homologous sequence used as a template for DNA repair synthesis. Therefore, HR is highly accurate and crucial for genome stability. Rad51 filament formation is controlled by positive and negative factors. In Saccharomyces cerevisiae, the mediator protein Rad52 catalyzes...

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Identifiers

PMID: 34207997
DOI: 10.3390/cells10061467
PMCID: PMC8230603

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