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Reappearance from Obscurity: Mammalian Rad52 in Homologous Recombination

14 Sept 2016

Abstract excerpt

Homologous recombination (HR) plays an important role in maintaining genomic integrity. It is responsible for repair of the most harmful DNA lesions, DNA double-strand breaks and inter-strand DNA cross-links. HR function is also essential for proper segregation of homologous chromosomes in meiosis, maintenance of telomeres, and resolving stalled replication forks. Defects in HR often lead to genetic diseases and...

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PMID: 27649245
DOI: 10.3390/genes7090063

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