Article
Impaired dNKAP function drives genome instability and tumorigenic growth in Drosophila epithelia.
Journal of molecular cell biology - 10 Apr 2024
Guo Ting, Miao Chen, Liu Zhonghua, Duan Jingwei, Ma Yanbin, Zhang Xiao, Yang Weiwei, Xue Maoguang, Deng Qiannan, Guo Pengfei, Xi Yongmei, Yang Xiaohang, Huang Xun, Ge Wanzhong
Abstract excerpt
Mutations or dysregulated expression of NF-kappaB-activating protein (NKAP) family genes have been found in human cancers. How NKAP family gene mutations promote tumor initiation and progression remains to be determined. Here, we characterized dNKAP, the Drosophila homolog of NKAP, and showed that impaired dNKAP function causes genome instability and tumorigenic growth in a Drosophila epithelial tumor model....
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