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Article

Unveiling the Tumor Suppressors: Insights from Drosophila.

Advances in experimental medicine and biology - 1 Jan 2025

Kuang Xiaoyu, Ma Xianjue

Abstract excerpt

Tumor suppressor genes (TSGs) play a crucial role in maintaining tissue homeostasis, and their loss can lead to uncontrolled overgrowth. For over 50 years, Drosophila has been a pivotal organism for identifying and studying novel TSGs in vivo. This chapter focuses on two types of TSGs that regulate cell growth: hyperplastic TSGs and neoplastic TSGs. Loss of hyperplastic TSGs will result in cell overgrowth without...

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PMID: 40745133
DOI: 10.1007/978-3-031-97035-1_1

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