Article

dSTK10 maintains tissue homeostasis by preventing JNK-mediated apoptosis

2023-02-01

Abstract excerpt

<h4>Background: </h4> The c-Jun N-terminal kinase (JNK) pathway is an evolutionarily conserved regulator of cell death, which is essential for coordinating tissue homeostasis. In this study, we have characterized the Drosophila Ste20-like kinase dSTK10 as a novel modulator of JNK pathway-mediated apoptotic cell death. <h4>Results: </h4> First, ectopic JNK signaling-triggered cell death is enhanced in heterozygous...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 696791a1-a70a-5d87-9286-11bb7903d58b
DOI: 10.21203/rs.3.rs-2526465/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

dSTK10 maintains tissue homeostasis by preventing JNK-mediated apoptosisDOI 10.21203/rs.3.rs-2526465/v1Read

GLYAT regulates JNK-mediated cell death in Drosophila.Semantic proximity Read

The Drosophila sterile-20 kinase slik controls cell proliferation and apoptosis during imaginal disc development.Semantic proximity Read

JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila.Semantic proximity Read

Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper.Semantic proximity Read

Dissecting JNK signaling, one KKKinase at a time.Semantic proximity Read

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.Semantic proximity Read

A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK.Semantic proximity Read

Drosophila happyhour modulates JNK-dependent apoptosis.Semantic proximity Read

Cross-Species Insights from ART-D to Uncover Evolutionarily Conserved Oncogenic MechanismsSemantic proximity Read

TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development.Semantic proximity Read

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling.Semantic proximity Read

Impaired dNKAP function drives genome instability and tumorigenic growth in Drosophila epithelia.Semantic proximity Read