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Aneuploidy-induced delaminating cells drive tumorigenesis in <i>Drosophila</i> epithelia

26 Nov 2012

Abstract excerpt

Genomic instability has been observed in essentially all sporadic carcinomas. Here we use Drosophila epithelial cells to address the role of chromosomal instability in cancer development as they have proved useful for elucidating the molecular mechanisms underlying tumorigenic growth. We first show that chromosomal instability leads to an apoptotic response. Interestingly, this response is p53 independent, as...

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PMID: 23184991
DOI: 10.1073/pnas.1206675109

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