Drosophila in cancer research: the first fifty tumor suppressor genes.

doi:10.1242/jcs.1994.supplement_18.4

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Article

Drosophila in cancer research: the first fifty tumor suppressor genes.

Journal of cell science. Supplement - 1 Jan 1994

Watson K L, Justice R W, Bryant P J

Abstract excerpt

In Drosophila, over 50 genes have been identified in which loss-of-function mutations lead to excess cell proliferation in the embryo, in the central nervous system, imaginal discs or hematopoietic organs of the larva, or in the adult gonads. Twenty-two of these genes have been cloned and charact...

Topics

Amino Acid Sequence
Animals
Drosophila
Genes, Insect
Genes, Tumor Suppressor
Humans
Molecular Sequence Data
Mutation
Neoplasms

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