Article

Loss of Nkd1 is epistatic to loss of Axin2 in regulating Wnt signaling

2023-11-02

Abstract excerpt

Wnt signaling is a crucial developmental pathway involved in early development as well as stem cell maintenance in adults and its misregulation leads to numerous diseases. Thus, understanding the regulation of this pathway becomes vitally important. Axin2 and Nkd1 are widely utilized negative feedback regulators in Wnt signaling where Axin2 functions to destabilize cytoplasmic β-catenin, and Nkd1 functions to inhi...

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Literature Corpus work: a584d48e-b78d-5097-a817-942660b0fe30
DOI: 10.1101/2023.10.30.563773

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