Article
JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila.
Cell death and differentiation - 1 Jul 2006
Lee J H, Koh H, Kim M, Park J, Lee S Y, Lee S, Chung J
Abstract excerpt
Although recent progresses have unveiled the diverse in vivo functions of LKB1, detailed molecular mechanisms governing these processes still remain enigmatic. Here, we showed that Drosophila LKB1 negatively regulates organ growth by caspase-dependent apoptosis, without affecting cell size and cell cycle progression. Through genetic screening for LKB1 modifiers, we discovered the JNK pathway as a novel component...
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