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Article

The double-edged sword of Notch signaling in cancer.

Seminars in cell & developmental biology - 1 Jun 2012

South Andrew P, Cho Raymond J, Aster Jon C

Abstract excerpt

Recent deep sequencing of cancer genomes has produced an explosion of new data implicating Notch signaling in several human cancers. Unlike most other pathways, these data indicate that Notch signaling can be either oncogenic or tumor suppressive, depending on the cellular context. In some instances, these relationships were predicted from mouse models or presaged by developmental roles for Notch, but in other...

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Identifiers

PMID: 22309843
DOI: 10.1016/j.semcdb.2012.01.017
PMCID: PMC3360804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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