Article

Cross-Species Insights from ART-D to Uncover Evolutionarily Conserved Oncogenic Mechanisms

2025-10-20

Abstract excerpt

Cancer arises from oncogenic clones, yet the dynamic mechanisms governing their stepwise evolution toward malignancy remain incompletely understood. Here, we establish the Atlas of Ras -driven Tumors in Drosophila (ART-D), a systematic, cross-species platform that dissects the molecular and phenotypic trajectories of tumorigenesis through ten genetically defined Ras V12 -driven models. By integrating longitudi...

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Literature Corpus work: 32908844-3fc9-55cc-8239-7105bf70ebd0
DOI: 10.1101/2025.10.20.683390

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