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Article

Misshapen Disruption Cooperates with RasV12 to Drive Tumorigenesis.

Cells - 14 Apr 2021

Kong Du, Lu Jin-Yu, Li Xiaoqin, Zhao Sihua, Xu Wenyan, Fang Jinan, Wang Xing, Ma Xianjue

Abstract excerpt

Although RAS family genes play essential roles in tumorigenesis, effective treatments targeting RAS-related tumors are lacking, partly because of an incomplete understanding of the complex signaling crosstalk within RAS-related tumors. Here, we performed a large-scale genetic screen in Drosophila eye imaginal discs and identified Misshapen (Msn) as a tumor suppressor that synergizes with oncogenic Ras (RasV12) to...

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Identifiers

PMID: 33919765
DOI: 10.3390/cells10040894
PMCID: PMC8070713

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