Article

NKX2-1 controls lung cancer progression by inducing DUSP6 to dampen ERK activity

2021-03-04

Abstract excerpt

Lung cancer remains a leading cause of cancer death, with unclear mechanisms driving the transition to aggressive cancer with poor prognosis. The RAS→RAF→MEK→ERK pathway is hyper-activated in ∼50% of human lung adenocarcinoma (LUAD). An initial activating mutation induces homeostatic feedback mechanisms that limit ERK activity. Additional, undefined genetic hits overcome the feedback, leading to high ERK activity...

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Literature Corpus work: a15030ed-ab3a-5d16-96f6-f6497c43f42c
DOI: 10.1101/2021.03.04.433941

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