Article
Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain.
Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 2019
Svoboda Devon S, Barrasa M Inmaculada, Shu Jian, Rietjens Rosalie, Zhang Shupei, Mitalipova Maya, Berube Peter, Fu Dongdong, Shultz Leonard D, Bell George W, Jaenisch Rudolf
Abstract excerpt
Microglia are essential for maintenance of normal brain function, with dysregulation contributing to numerous neurological diseases. Protocols have been developed to derive microglia-like cells from human induced pluripotent stem cells (hiPSCs). However, primary microglia display major differences in morphology and gene expression when grown in culture, including down-regulation of signature microglial genes....
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