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Article

The chemotherapeutic agent doxorubicin induces brain senescence, with modulation by APOE genotype.

Experimental neurology - 1 Jan 2024

Demby Tamar, Gross Phillip S, Mandelblatt Jeanne, Huang Jeffrey K, Rebeck G William

Abstract excerpt

Many cancer patients experience serious cognitive problems related to their treatment, which can greatly affect their quality of life. The molecular mechanisms of this cancer chemotherapy-induced cognitive impairment (CICI) are unknown, thus slowing the development of preventative approaches. We hypothesized that cancer chemotherapies could induce cellular senescence in the brain, creating a pro-inflammatory...

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Identifiers

PMID: 37944881
DOI: 10.1016/j.expneurol.2023.114609
PMCID: PMC11302516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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