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Article

Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma.

Nature communications - 27 Jan 2023

Salam Rana, Saliou Alexa, Bielle Franck, Bertrand Mathilde, Antoniewski Christophe, Carpentier Catherine, Alentorn Agusti, Capelle Laurent, Sanson Marc, Huillard Emmanuelle, Bellenger Léa, Guégan Justine, Le Roux Isabelle

Abstract excerpt

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, yet it remains refractory to systemic therapy. Elimination of senescent cells has emerged as a promising new treatment approach against cancer. Here, we investigated the contribution of senescent cells to GBM progression. Senescent cells are identified in patient and mouse GBMs. Partial removal of p16Ink4a-expressing malignant...

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Identifiers

PMID: 36707509
DOI: 10.1038/s41467-023-36124-9
PMCID: PMC9883514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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