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Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

20 Jan 2021

Abstract excerpt

Abstract Cellular senescence is characterized by an irreversible cell cycle arrest and a pro‐inflammatory senescence‐associated secretory phenotype (SASP), which is a major contributor to aging and age‐related diseases. Clearance of senescent cells has been shown to improve brain function in mouse models of neurodegenerative diseases. However, it is still unknown whether senescent cell clearance alleviates...

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PMID: 33470505
DOI: 10.1111/acel.13296

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