Article

DNA damage-induced senescence reshapes transcriptomic and functional landscape of human neural progenitor cells

2026-05-01

Abstract excerpt

Ageing-related decline in hippocampal neurogenesis has been associated with cognitive impairment and neurodegenerative disease, yet experimentally tractable human models to study the underlying cellular and molecular mechanisms remain limited. Cellular senescence has emerged as a candidate driver of age-related tissue dysfunction, but its induction and consequences in human NPCs have not been well characterized. H...

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Literature Corpus work: 2233c3de-153a-5e52-bfb2-c182bee71ddb
DOI: 10.64898/2026.04.29.721535

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