Article

DNA damage and senescence in the aging and Alzheimer’s disease cortex are not uniformly distributed

2024-04-30

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a neurodegenerative illness with a typical age of onset exceeding 65 years of age. The age-dependency of the condition led us to track the appearance of DNA damage in the frontal cortex of individuals who died with a diagnosis of AD. The focus on DNA damage was motivated by evidence that increasing levels of irreparable DNA damage are a major driver of the aging proce...

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Literature Corpus work: 75b159a4-3208-51ac-a61e-682dba819f37
DOI: 10.1101/2024.04.28.591529

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