Article
Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma
2022-05-19
Abstract excerpt
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, yet it remains refractory to systemic therapy. Elimination of senescent cells has emerged as a promising new treatment approach against cancer. Here, we investigated the contribution of senescent cells to GBM progression. Senescent cells were identified in patient and mouse GBMs. Partial removal of p16 Ink4a -expressing malignant senes...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- f0b33f3e-62d0-512b-8d9e-314c19395fb1
- DOI
- 10.1101/2022.05.18.492465