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Article

Influence of ApoE genotype on doxorubicin-induced cognitive impairment in juvenile rats.

Scientific reports - 24 Dec 2025

Patel Chadni, Diglio Frank, Durham Benjamin H, Cole Peter D

Abstract excerpt

Many pediatric cancer survivors experience chemotherapy-induced cognitive impairment (CICI), which negatively impacts their quality of life. However, while some patients develop CICI, others do not, suggesting that genetic variants may contribute to the development of CICI. The Apolipoprotein E (ApoE) E4 allele has been identified as a risk variant for CICI among pediatric cancer survivors. However, the...

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Identifiers

PMID: 41436539
DOI: 10.1038/s41598-025-33104-5
PMCID: PMC12749423

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GFAP

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