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Different Mechanisms in Doxorubicin-Induced Neurotoxicity: Impact of BRCA Mutations

15 May 2025

Abstract excerpt

The genotoxic drug doxorubicin (Dox) remains one of the most powerful chemotherapeutic options available for a wide range of cancers including breast, ovarian, and other cancers. However, emerging evidence links Dox treatment with chemotherapy-induced cognitive impairment, a condition that is popularly referred to as Dox-induced neurotoxicity or "chemobrain", which limits the use of the drug. There are no...

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PMID: 40429877
DOI: 10.3390/ijms26104736

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