Article

Transcriptional profiling reveals a previously unknown population of Cdkn2a-positive tumor-associated macrophages in aggressive brain cancer

2024-10-21

Abstract excerpt

Microglia, the resident immune cells of the Central Nervous System (CNS), play crucial roles in homeostasis, immune responses, and the modulation of neuronal functions. In brain tumors, microglia are difficult to distinguish from infiltrating macrophages and are collectively called Tumor-Associated Macrophages (TAMs). While these cells exhibit plasticity, support tumor growth, and suppress antitumor immune respons...

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Literature Corpus work: 0f6e9533-947f-5b8c-b4ed-3eb605231f85
DOI: 10.1101/2024.10.17.618451

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