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Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons.

Aging cell - 1 May 2026

Gerónimo-Olvera Cristian, Scheeler Stephen M, Aguirre Carlos Galicia, Vega-Hormazabal Genesis, Garcia Daniela, Wu Long, Murad Natalia, Schneider Kevin, Wilson Kenneth A, Markov Nikola T, Song Sicheng, Simons Jesse, Gerencser Akos A, Parlan Emily, Mooney Sean D, Verdin Eric, Campisi Judith, Tracy Tara E, Furman David, Melov Simon, Ellerby Lisa M

Abstract excerpt

Genome-wide association studies (GWAS) have identified APOE2 allele as linked to exceptional longevity, with carriers exhibiting a reduced risk of Alzheimer's disease (AD). Apolipoprotein E (APOE), a glycoprotein involved in lipid transport, has three major alleles. However, alterations in lipid metabolism alone do not fully explain APOE2's protective effects. In contrast, APOE4 is the strongest genetic risk...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42103698
DOI: 10.1111/acel.70494
PMCID: PMC13156074

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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