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Article

Glycidamide-induced hypermutation in yeast single-stranded DNA reveals a ubiquitous clock-like mutational motif in humans.

Nucleic acids research - 22 Sept 2023

Hudson Kathleen M, Klimczak Leszek J, Sterling Joan F, Burkholder Adam B, Kazanov Marat D, Saini Natalie, Mieczkowski Piotr A, Gordenin Dmitry A

Abstract excerpt

Mutagens often prefer specific nucleotides or oligonucleotide motifs that can be revealed by studying the hypermutation spectra in single-stranded (ss) DNA. We utilized a yeast model to explore mutagenesis by glycidamide, a simple epoxide formed endogenously in humans from the environmental toxicant acrylamide. Glycidamide caused ssDNA hypermutation in yeast predominantly in cytosines and adenines. The most...

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Identifiers

PMID: 37471042
DOI: 10.1093/nar/gkad611
PMCID: PMC10516655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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