Article
Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.
Molecular cell - 25 May 2012
Roberts Steven A, Sterling Joan, Thompson Cole, Harris Shawn, Mav Deepak, Shah Ruchir, Klimczak Leszek J, Kryukov Gregory V, Malc Ewa, Mieczkowski Piotr A, Resnick Michael A, Gordenin Dmitry A
Abstract excerpt
Mutations are typically perceived as random, independent events. We describe here nonrandom clustered mutations in yeast and in human cancers. Genome sequencing of yeast grown under chronic alkylation damage identified mutation clusters that extend up to 200 kb. A predominance of "strand-coordinated" changes of either cytosines or guanines in the same strand, mutation patterns, and genetic controls indicated that...
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