Article

Motif-Centered Analyses Reveal Universal and Tissue-Specific Mutagenic Mechanisms Operating in the Human Body

2025-10-08

Abstract excerpt

Somatic mutations are inevitable in human genomes and can lead to tumorigenesis, yet baseline mutagenesis in non-cancerous normal cells remain poorly understood. Here, we analyzed the mutation profiles of 11,949 normal samples across 25 tissues obtained from whole-genome and whole-exome sequencing datasets. We applied stringent statistical hypothesis for detecting enrichment and enrichment-adjusted Minimal Estimat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5f028822-3f47-523e-99d0-62b399edc4d8
DOI: 10.1101/2025.10.07.681015

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Motif-Centered Analyses Reveal Universal and Tissue-Specific Mutagenic Mechanisms Operating in the Human BodyDOI 10.1101/2025.10.07.681015Read

Comparing the predictors of mutability among healthy human tissues inferred from mutations in single-cell genome data.Semantic proximity Read

Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia.Semantic proximity Read

Base changes in tumour DNA have the power to reveal the causes and evolution of cancer.Semantic proximity Read

The Repertoire of Mutational Signatures in Human CancerSemantic proximity Read

Comparing the predictors of mutability among healthy human tissues inferred from mutations in single cell genome dataSemantic proximity Read

Signatures of mutational processes in human cancer.Semantic proximity Read

The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selectionSemantic proximity Read

Somatic mutation load and spectra: A record of DNA damage and repair in healthy human cells.Semantic proximity Read

The repertoire of mutational signatures in human cancer.Semantic proximity Read

Patterns and processes of somatic mutations in nine major cancers.Semantic proximity Read

The somatic mutation landscape of the human bodySemantic proximity Read

APOBEC-Induced Mutagenesis in Cancer.Semantic proximity Read