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Article

Mutation signatures specific to DNA alkylating agents in yeast and cancers.

Nucleic acids research - 17 Apr 2020

Saini Natalie, Sterling Joan F, Sakofsky Cynthia J, Giacobone Camille K, Klimczak Leszek J, Burkholder Adam B, Malc Ewa P, Mieczkowski Piotr A, Gordenin Dmitry A

Abstract excerpt

Alkylation is one of the most ubiquitous forms of DNA lesions. However, the motif preferences and substrates for the activity of the major types of alkylating agents defined by their nucleophilic substitution reactions (SN1 and SN2) are still unclear. Utilizing yeast strains engineered for large-scale production of single-stranded DNA (ssDNA), we probed the substrate specificity, mutation spectra and signatures...

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Identifiers

PMID: 32133535
DOI: 10.1093/nar/gkaa150
PMCID: PMC7144945

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