Motif-centered analyses reveal universal and tissue-specific mutagenic mechanisms operating in the human body.

Abstract excerpt

Somatic mutations are inevitable in human genomes and can lead to cancer initiation and tumor progression. Although many mutagenic processes have been linked to cancer, their activities in normal tissues before malignant transformation remain poorly characterized. Here, we analyzed the mutation profiles of 10,625 normal samples across 25 tissues obtained from whole-genome and whole-exome sequencing datasets. We...

Topics

• Humans
• Mutagenesis
• Mutation
• Neoplasms
• Nucleotide Motifs
• Organ Specificity
• Exome Sequencing