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5-Chloro-2'-deoxycytidine Induces a Distinctive High-Resolution Mutational Spectrum of Transition Mutations In Vivo.

Chemical research in toxicology - 18 Mar 2024

Chancharoen Marisa, Yang Zhiyu, Dalvie Esha D, Gubina Nina, Ruchirawat Mathuros, Croy Robert G, Fedeles Bogdan I, Essigmann John M

Abstract excerpt

The biomarker 5-chlorocytosine (5ClC) appears in the DNA of inflamed tissues. Replication of a site-specific 5ClC in a viral DNA genome results in C → T mutations, which is consistent with 5ClC acting as a thymine mimic in vivo. Direct damage of nucleic acids by immune-cell-derived hypochlorous acid is one mechanism by which 5ClC could appear in the genome. A second, nonmutually exclusive mechanism involves...

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PMID: 38394377
DOI: 10.1021/acs.chemrestox.3c00358
PMCID: PMC10952010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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