Article

Methylglyoxal mutagenizes single-stranded DNA via Rev1-associated slippage and mispairing

2025-03-18

Abstract excerpt

Methylglyoxal (MG) is a highly reactive aldehyde that is produced endogenously during metabolism and is derived from exogenous sources such as sugary food items and cigarette smoke. Unless detoxified by glyoxalases (Glo1 and Glo2), MG can readily react with all major biomolecules, including DNA and proteins, generating characteristic lesions and glycation-derived by- products. As a result, MG exposure has been lin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4f59c61-13a1-5603-80f1-0b584057ed4c
DOI: 10.1101/2025.03.18.643935

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Methylglyoxal mutagenizes single-stranded DNA via Rev1-associated slippage and mispairingDOI 10.1101/2025.03.18.643935Read

Methylglyoxal mutagenizes single-stranded DNA via Rev1-associated slippage and mispairing.Semantic proximity Read

Glycidamide-induced hypermutation in yeast single-stranded DNA reveals a ubiquitous clock-like mutational motif in humans.Semantic proximity Read

Acetaldehyde makes a distinct mutation signature in single-stranded DNA.Semantic proximity Read

Click-chemistry-aided quantitation and sequencing of oxidized guanines and apurinic sites uncovers their transcription-linked strand bias in human cellsSemantic proximity Read

Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.Semantic proximity Read

Hierarchical determinants of the oxidation-induced mutational landscape in human cellsSemantic proximity Read

Contributing factors to the oxidation-induced mutational landscape in human cells.Semantic proximity Read

Mutation signatures specific to DNA alkylating agents in yeast and cancers.Semantic proximity Read

DNA Glycosylases Define the Outcome of Endogenous Base Modifications.Semantic proximity Read

Error-free versus mutagenic processing of genomic uracil—Relevance to cancerSemantic proximity Read

High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing.Semantic proximity Read

Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistanceSemantic proximity Read