Article
Atypical UV Photoproducts Induce Non-canonical Mutation Classes Associated with Driver Mutations in Melanoma.
Cell reports - 17 Nov 2020
Laughery Marian F, Brown Alexander J, Bohm Kaitlynne A, Sivapragasam Smitha, Morris Haley S, Tchmola Mila, Washington Angelica D, Mitchell Debra, Mather Stephen, Malc Ewa P, Mieczkowski Piotr A, Roberts Steven A, Wyrick John J
Abstract excerpt
Somatic mutations in skin cancers and other ultraviolet (UV)-exposed cells are typified by C>T and CC>TT substitutions at dipyrimidine sequences; however, many oncogenic "driver" mutations in melanoma do not fit this UV signature. Here, we use genome sequencing to characterize mutations in yeast repeatedly irradiated with UV light. Analysis of ~50,000 UV-induced mutations reveals abundant non-canonical mutations,...
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