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Article

Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA.

Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 2005

Auerbach Paul, Bennett Richard A O, Bailey Elisabeth A, Krokan Hans E, Demple Bruce

Abstract excerpt

Abasic [apurinic/apyrimidinic (AP)] sites are common, noncoding DNA lesions. Despite extensive investigation, the mutational pattern they provoke in eukaryotic cells remains unresolved. We constructed Saccharomyces cerevisiae strains in which chromosomal AP sites were generated during normal cell growth by altered human uracil-DNA glycosylases that remove undamaged cytosines or thymines. The mutation target was...

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Identifiers

PMID: 16314579
DOI: 10.1073/pnas.0504643102
PMCID: PMC1308887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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