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Article

Acetaldehyde makes a distinct mutation signature in single-stranded DNA.

Nucleic acids research - 22 Jul 2022

Vijayraghavan Sriram, Porcher Latarsha, Mieczkowski Piotr A, Saini Natalie

Abstract excerpt

Acetaldehyde (AA), a by-product of ethanol metabolism, is acutely toxic due to its ability to react with various biological molecules including DNA and proteins, which can greatly impede key processes such as replication and transcription and lead to DNA damage. As such AA is classified as a group 1 carcinogen by the International Agency for Research on Cancer (IARC). Previous in vitro studies have shown that AA...

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Identifiers

PMID: 35776120
DOI: 10.1093/nar/gkac570
PMCID: PMC9303387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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