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Article

Methylglyoxal mutagenizes single-stranded DNA via Rev1-associated slippage and mispairing.

Nucleic acids research - 19 Jul 2025

Vijayraghavan Sriram, Ruggiero Alessandra, Becker Samuel, Mieczkowski Piotr, Hanna George S, Hamann Mark T, Saini Natalie

Abstract excerpt

Methylglyoxal (MG) is a highly reactive aldehyde that is produced endogenously during metabolism, and from exogenous sources like sugary food and cigarette smoke. Unless detoxified by glyoxalases, MG can readily react with DNA and proteins, generating characteristic glycation-derived lesions. As a result, MG exposure has been linked to a variety of human diseases, including cancers. Prior studies show that MG...

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Identifiers

PMID: 40705923
DOI: 10.1093/nar/gkaf705
PMCID: PMC12288878

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