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Article

Analyses of mutational patterns induced by formaldehyde and acetaldehyde reveal similarity to a common mutational signature.

G3 (Bethesda, Md.) - 4 Nov 2022

Thapa Mahanish J, Fabros Reena M, Alasmar Salma, Chan Kin

Abstract excerpt

Formaldehyde and acetaldehyde are reactive small molecules produced endogenously in cells as well as being environmental contaminants. Both of these small aldehydes are classified as human carcinogens, since they are known to damage DNA and exposure is linked to cancer incidence. However, the mutagenic properties of formaldehyde and acetaldehyde remain incompletely understood, at least in part because they are...

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Identifiers

PMID: 36073936
DOI: 10.1093/g3journal/jkac238
PMCID: PMC9635668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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