Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas.

Epigenetics & chromatin - 28 Apr 2023

Wang Xinyu, Dai Lijun, Liu Yang, Li Chenghao, Fan Dandan, Zhou Yue, Li Pengcheng, Kong Qingran, Su Jianzhong

Abstract excerpt

BACKGROUND: IDH1/2 hotspot mutations are well known to drive oncogenic mutations in gliomas and are well-defined in the WHO 2021 classification of central nervous system tumors. Specifically, IDH mutations lead to aberrant hypermethylation of under-methylated regions (UMRs) in normal tissues through the disruption of TET enzymes. However, the chromatin reprogramming and transcriptional changes induced by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Glioma

Share to Isocitrate Dehydrogenase

Share to Mutation

Share to Oncogenes

Source

Open in PubMed Open full text

Identifiers

PMID: 37118755
DOI: 10.1186/s13072-023-00490-x
PMCID: PMC10142198

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas.PMID 37118755Read ↗

Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence.Semantic proximity Read ↗

Region-specific DNA hydroxymethylation along the malignant progression of IDH-mutant gliomas.Semantic proximity Read ↗

Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.Semantic proximity Read ↗

The epigenetic evolution of gliomas is determined by their IDH1 mutation status and treatment regimenSemantic proximity Read ↗

DNA Methylation Profiling in IDH-Mutant Gliomas: Biological Evolution, Molecular Grading and Clinical Implementation.Semantic proximity Read ↗

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.Semantic proximity Read ↗

The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen.Semantic proximity Read ↗

DNA methylation profiling reveals a novel subtype harboring IDH mutation in H3-altered gliomas.Semantic proximity Read ↗

Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas.Semantic proximity Read ↗

Methylation and transcription patterns are distinct in IDH mutant gliomas compared to other IDH mutant cancersSemantic proximity Read ↗

Single-cell multimodal glioma analyses reveal epigenetic regulators of cellular plasticity and environmental stress responseSemantic proximity Read ↗

Integrated genomic characterization of IDH1-mutant glioma malignant progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.