Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.

Nature genetics - 1 Jul 2026

Nomura Masashi, Raviram Ramya, Schiffman Joshua S, Bussema Lillian, Lu Vivian, Wheeler Noelle, Lee John J Y, Fan Yilin, Zheng Mian Hua, Ruiz Florian, Danish Husain, Kellett Sorcha, Nusrat Labeeba, Chaligne Ronan, Huse Jason T, Yung W K Alfred, Tanaka Shota, Saito Nobuhito, Das Sunit, Potenski Catherine, Landau Dan A, Suvà Mario L

Abstract excerpt

The progression of isocitrate dehydrogenase-mutant glioma (IDH-G) from slow-growing tumor to fatal disease is associated with transcriptional and DNA methylation changes that remain poorly understood. Here, we profiled a longitudinal cohort of 36 IDH-G samples from 19 patients by joint-capture multi-omic single-nucleus DNA methylation, single-nucleus RNA sequencing and bulk exome sequencing. We show that IDH-G...

Topics

Join the communities discussing this publication.

Brain Neoplasms
Disease Progression
DNA Methylation
Exome Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isocitrate Dehydrogenase

Longitudinal Studies

Neoplastic Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 42332268
DOI: 10.1038/s41588-026-02642-7
PMCID: PMC13364636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.PMID 42332268Read ↗

Acquired genetic and cell-state changes in IDH-mutant glioma progression.Semantic proximity Read ↗

Single-nucleus multiomics unveils malignant cellular states, regulatory architectures and microenvironmental reorganization across the G-CIMP epigenomic transition in IDH-mutant gliomaSemantic proximity Read ↗

Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomicsSemantic proximity Read ↗

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seqSemantic proximity Read ↗

Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell MultiomicsSemantic proximity Read ↗

Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas.Semantic proximity Read ↗

Single-cell multimodal glioma analyses reveal epigenetic regulators of cellular plasticity and environmental stress responseSemantic proximity Read ↗

Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence.Semantic proximity Read ↗

DNA Methylation Profiling in IDH-Mutant Gliomas: Biological Evolution, Molecular Grading and Clinical Implementation.Semantic proximity Read ↗

Patient-derived cells from recurrent tumors that model the evolution of IDH-mutant gliomaSemantic proximity Read ↗

Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response.Semantic proximity Read ↗

A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade gliomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.