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Article

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.

Nature - 15 Feb 2012

Turcan Sevin, Rohle Daniel, Goenka Anuj, Walsh Logan A, Fang Fang, Yilmaz Emrullah, Campos Carl, Fabius Armida W M, Lu Chao, Ward Patrick S, Thompson Craig B, Kaufman Andrew, Guryanova Olga, Levine Ross, Heguy Adriana, Viale Agnes, Morris Luc G T, Huse Jason T, Mellinghoff Ingo K, Chan Timothy A

Abstract excerpt

Both genome-wide genetic and epigenetic alterations are fundamentally important for the development of cancers, but the interdependence of these aberrations is poorly understood. Glioblastomas and other cancers with the CpG island methylator phenotype (CIMP) constitute a subset of tumours with ex...

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Identifiers

PMID: 22343889
DOI: 10.1038/nature10866
PMCID: PMC3351699

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22343889-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.PMID 22343889Read ↗

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