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Methylation and transcription patterns are distinct in IDH mutant gliomas compared to other IDH mutant cancers

20 Jun 2019

Abstract excerpt

Abstract Mutations in isocitrate dehydrogenases 1 and 2 (IDH mut ) are present in a variety of cancers, including glioma, acute myeloid leukemia (AML), melanoma, and cholangiocarcinoma. These mutations promote hypermethylation, yet it is only a favorable prognostic marker in glioma, for reasons that are unclear. We hypothesized that the patterns of DNA methylation, and transcriptome profiles, would vary among IDH...

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PMID: 31222125
DOI: 10.1038/s41598-019-45346-1

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