Integrated genomic characterization of IDH1-mutant glioma malignant progression.

doi:10.1038/ng.3457

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Article

Integrated genomic characterization of IDH1-mutant glioma malignant progression.

Nature genetics - 1 Jan 2016

Bai Hanwen, Harmancı Akdes Serin, Erson-Omay E Zeynep, Li Jie, Coşkun Süleyman, Simon Matthias, Krischek Boris, Özduman Koray, Omay S Bülent, Sorensen Eric A, Turcan Şevin, Bakırcığlu Mehmet, Carrión-Grant Geneive, Murray Phillip B, Clark Victoria E, Ercan-Sencicek A Gulhan, Knight James, Sencar Leman, Altınok Selin, Kaulen Leon D, Gülez Burcu, Timmer Marco, Schramm Johannes, Mishra-Gorur Ketu, Henegariu Octavian, Moliterno Jennifer, Louvi Angeliki, Chan Timothy A, Tannheimer Stacey L, Pamir M Necmettin, Vortmeyer Alexander O, Bilguvar Kaya, Yasuno Katsuhito, Günel Murat

Abstract excerpt

Gliomas represent approximately 30% of all central nervous system tumors and 80% of malignant brain tumors. To understand the molecular mechanisms underlying the malignant progression of low-grade gliomas with mutations in IDH1 (encoding isocitrate dehydrogenase 1), we studied paired tumor samples from 41 patients, comparing higher-grade, progressed samples to their lower-grade counterparts. Integrated genomic...

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Identifiers

PMID: 26618343
DOI: 10.1038/ng.3457
PMCID: PMC4829945

Genes

IDH1
FOXM1
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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