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DNA Methylation Profiling in IDH-Mutant Gliomas: Biological Evolution, Molecular Grading and Clinical Implementation.

Neuropathology and applied neurobiology - 1 Aug 2026

Tralongo Pietro, Ricciardi Gabriele, Ballato Mariagiovanna, Fiorentino Vincenzo, Zuccalà Valeria, Castellani Giorgia, D'Alessandris Quintino Giorgio, Fadda Guido, Ricci-Vitiani Lucia, Caffo Maria, Martini Maurizio

Abstract excerpt

Mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2) define a major subgroup of adult-type diffuse gliomas and induce accumulation of D-2-hydroxyglutarate, resulting in extensive DNA and histone methylation changes. This epigenetic reprogramming underlies the glioma CpG island methylator phenotype (G-CIMP) and contributes to tumour lineage, differentiation state and clinical behaviour. DNA methylation profiling...

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Source

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Identifiers

PMID: 42630077
DOI: 10.1111/nan.70100
PMCID: PMC13498940

Genes

CDKN2A
IDH1
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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