Article

The epigenetic evolution of gliomas is determined by their IDH1 mutation status and treatment regimen

2021-08-11

Abstract excerpt

<h4>Summary</h4> Tumor adaptation or selection is thought to underlie therapy resistance of gliomas. To investigate the longitudinal epigenetic evolution of gliomas in response to therapeutic pressure, we performed an epigenomic analysis of 143 matched initial and recurrent patients with IDH-wildtype (IDHwt) and IDH-mutant (IDHmut) gliomas. IDHwt gliomas showed a longitudinally stable epigenome with relatively lo...

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Literature Corpus work: e63eb55c-c14f-5b99-8584-0d83ac698174
DOI: 10.1101/2021.08.09.455687

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